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目的:探讨儿童过敏性哮喘的特应性体质与血清总免疫球蛋白E水平的相关性。方法:2011年1月~2013年7月在我院就诊的儿童过敏性哮喘130例作为观察组(吸入性过敏原70例,食物性过敏原60例),选择同期来我院健康体检儿童130例作为对照组,两组都进行了血清IL-4和IgE含量检测,并进行了相关性分析。结果:观察组患儿的血清IL-4和IgE含量都明显高于对照组(P<0.05),不同特异性体质患儿的血清IL-4和IgE含量对比差异无统计学意义(P>0.05)。Pearson直线相关分析显示不同特应性体质的患儿血清IL-4和IgE含量呈正向相关性(P<0.05)。结论:儿童过敏性哮喘表现为不同的特应性体质,都伴随有血清IL-4和IgE水平明显升高,提示IgE与IL-4都是哮喘发病中的重要调节因子。
Objective: To investigate the correlation between atopic constitution and serum total immunoglobulin E in children with allergic asthma. Methods: From January 2011 to July 2013, 130 children with allergic asthma in our hospital were selected as the observation group (70 cases of inhaled allergens and 60 cases of foodborne allergens). The children of 130 Cases as a control group, serum IL-4 and IgE levels were detected in both groups, and the correlation analysis. Results: Serum levels of IL-4 and IgE in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in serum IL-4 and IgE levels in children with different specific constitutions (P> 0.05 ). Pearson’s linear correlation analysis showed that there was a positive correlation between serum IL-4 and IgE in children with different atopic bodies (P <0.05). CONCLUSIONS: Allergic asthma in children manifests itself in different atopic constitutions, accompanied by a significant increase in serum IL-4 and IgE levels, suggesting that both IgE and IL-4 are important regulators of asthma.