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本文报告了胎肝移植(FLT)治疗两例重型β—地中海贫血(β—地贫)患儿.患儿经全身照射加环磷酰胺(TBI+CY)预处理后,分别输入了3～4个胎肝制备的悬液,未使用MTX预防GVHD.移植后外周血及骨髓出现一过性造血障碍,30天左右造血恢复。植后20～123天两例外周血均出现供体型染色体核型,例1皮肤活检有轻度GVHD表现,表明此期嵌合作形成.两个月后两例均恢复自身造血.移植后5个月内未输血;例1移植后21个月内仅输血3次.
This article reports the treatment of two cases of severe β-thalassemia with fetal liver transplantation (FLT) in children with systemic β-thalassemia plus systemic cyclophosphamide (TBI + CY) A suspension of fetal liver preparation, did not use MTX to prevent GVHD. Transplantation of peripheral blood and bone marrow appeared a transient hematopoietic disorders, about 30 days to restore hematopoietic. There were donor-type karyotypes in peripheral blood of two cases between the days of 20 and 123 days after implantation, with mild GVHD manifestations on skin biopsy in one case, demonstrating that chimerism was formed in both cases.2 After two months, all patients recovered their hematopoiesis No blood transfusion in the month; Example 1 Transfusion only 3 times within 21 months after transplantation.