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目的 :评价 IGF- 和 IGFBP- 3在诊断 GHD中的价值。方法 :采用化学发光免疫法检测 6 0例青春发育前期矮小儿童的血清生长激素 (GH) ,酶联免疫法 (ELISA)检测 IGF- 和 IGFBP- 3。根据 GH峰值≤ 5μg/L为完全性生长激素缺乏 (CGHD) ,>5μg/L～ 10μg/L为部分性生长激素缺乏 ,>10μg/L为特发性矮身材 (ISS) ,并与 2 0例健康儿童对照。结果 :CGHD组 IGF- 和 IGFBP- 3值较其它三组明显降低 (P<0 .0 5 )。CGHD患儿 IGF- 的敏感性为 10 0 % ,特异性 6 5 .6 % ,试验正确性 80 % ;IGFBP- 3的敏感性为 96 .4 % ,特异性 71.8% ,试验正确性 83.3% ,IGF- 和 IGFBP- 3同时检测 ,其敏感性为 96 .4 % ,特异性 75 % ,试验正确性 85 %。结论 :GHD者 IGF- 低于正常 ,尤以 IGFBP- 3为著 ,两者同步检测较单独检测更具诊断的正确性。
Objective: To evaluate the value of IGF- and IGFBP-3 in the diagnosis of GHD. Methods: Serum growth hormone (GH) of 60 young and early adolescent children were detected by chemiluminescence immunoassay. The levels of IGF- and IGFBP-3 were detected by enzyme-linked immunosorbent assay (ELISA). According to GHG ≤ 5μg / L for complete growth hormone deficiency (CGHD),> 5μg / L ~ 10μg / L partial growth hormone deficiency,> 10μg / L for idiopathic short stature (ISS), and 20 Cases of healthy children control. Results: The levels of IGF- and IGFBP-3 in CGHD group were significantly lower than those in the other three groups (P <0.05). The sensitivity of IGF-1 in CGHD children was 100%, specificity 65.5%, test correctness 80%; IGFBP-3 sensitivity 96.4%, specificity 71.8%, test correctness 83.3% IGF- and IGFBP-3 simultaneously detected, the sensitivity was 96.4%, specificity 75%, the correctness of the test 85%. CONCLUSIONS: IGF-1 in GHD is lower than normal, especially IGFBP-3. Simultaneous detection of both is more diagnostic than single detection.