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目的探讨NP和TP方案对晚期非小细胞肺癌(NscLc)的疗效和毒性。方法48例晚期NSCLC患者随机分成NP组和TP组，两组患者接受至少2个周期以上的NP或TP方案的化疗，比较两组化疗方案的近期疗效和毒副反应。结果 NP和7rP组近期疗效的有效率分别为46.2％、45.5％，中位生存期分别为10、9.5个月。两组疗效无显著统计学差异。两组均以白细胞降低及恶心呕吐为主，均在可耐受的范围内。结论 NP和TP化疗方案对晚期NSCLC均有较好的临床疗效，化疗毒副反应可耐受。NP和TP化疗方案均可作为晚期NSCLC的一线治疗方案。“,” Objective:To investigate the efficacy and toxicity of the NP and TP regimen on advanced non—smal cel lung cancer.Methods:48 cases with advanced non—smal cel lung cancer were divided into the NP and the TP group randomly.A11 cases accepted at least 2 cycles of chemotherapy.The short term efficacy and adverse effects of two groups were observed.Results:The short term effective rate of NP and TP group was 46.2%and 45.5%respectively;the median life cycle Was 10 and 9.5 months.There is no significant difference in two groups. Leukocytopenia, nausea and vomiting was the mainly adverse effects of treatment in two groups,but it was tolerable.Conclusion:Both NP and TP regimen show good clinical effect and tolerable adverse reaction.Both of them could become the original chemotherapy in the treatment of advanced non—smal cel lung cancer.