论文部分内容阅读
目的 研究尿激酶型纤溶酶原激活物受体 (uPAR)在胃癌浸润和转移过程中所起的作用。方法 采用免疫组化SP法检测 5 9例胃癌组织中uPAR的表达 ,观察其与癌组织学类型、浸润深度以及淋巴结转移的关系。结果 5 9例中uPAR阳性 2 8例 ;在乳头状、管状腺癌和粘液腺癌中uPAR阳性率较高 ,而在低分化癌和印戒细胞癌中阳性率较低 (P <0 .0 1) ;有淋巴结转移组uPAR阳性率为 6 0 .5 % (2 3/38) ,高于无淋巴结转移组的 2 3.8% (5 /2 1) (P <0 .0 1) ;uPAR在早期胃癌组阳性率为 12 .5 % (1/8) ,侵及肌层组阳性率为 38% (6 /16 ) ,侵犯全层组阳性率为 6 0 % (2 1/35 ) ,差别有显著性 (P <0 .0 5 )。结论 uPAR与胃癌的浸润和转移密切相关 ,也与胃癌组织学类型有关。
Objective To investigate the role of urokinase-type plasminogen activator receptor (uPAR) in the process of gastric cancer invasion and metastasis. Methods Immunohistochemical SP method was used to detect the expression of uPAR in 59 cases of gastric carcinoma and its relationship with histological type, depth of invasion and lymph node metastasis was observed. Results The positive rate of uPAR in papillary, tubular adenocarcinoma and mucinous adenocarcinoma in 59 cases was 28 cases, and the positive rate of uPAR was higher in poorly differentiated carcinoma and signet-ring cell carcinoma (P <0. 0 1). The positive rate of uPAR in patients with lymph node metastasis was 65.5% (2 3/38), which was higher than that in patients without lymph node metastasis (3.8%, P <0.01) The positive rate was 12.5% (1/8) in early gastric cancer group, 38% (6/16) in invasive muscle group, and 60% (2 1/35) in invasive group. The difference was significant There was significant (P <0.05). Conclusions uPAR is closely related to the infiltration and metastasis of gastric cancer and also to the histological type of gastric cancer.