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用卡托普利联合生脉注射液治疗60例肾综合征出血热(HFRS)急性肾功能衰竭(ARF)患者,并设常规治疗54例作为对照。结果治疗组血压恢复正常时间为2.7天±1.5天,对照组为5.2天±3.5天(P<0.01);治疗组少尿天数为3.1天±1.8天,对照组为4.82天±2.35天(P<0.01);治疗组多尿天数为6.55天±3.23天,对照组为9.38天±4.81天(P<0.01);治疗组尿蛋白转阴天数为4.03天±1.87天,对照组为7.52天±3.53天(P<0.01);治疗组尿素氮降至正常天数为6.12天±3.18天,对照组为10.21天±4.72天(P<0.01);治疗组并发症及死亡率均明显少于对照组。提示两药合用确能降低血压,减少尿蛋白的排出和改善肾功能,且未见明显不良反应。
Sixty patients with acute renal failure (ARF) with hemorrhagic fever with renal syndrome (HFRS) were treated with captopril combined with Shengmai injection, and 54 patients were treated by conventional therapy. Results The blood pressure recovery time was 2.7 days ± 1.5 days in the treatment group and 5.2 days ± 3.5 days in the control group (P <0.01). The number of oliguria days in the treatment group was 3.1 days ± 1.8 days and that in the control group was 4.82 days ± 2.35 days (P <0.01). The number of urination days in the treatment group was 6.55 days ± 3.23 days and that in the control group was 9.38 days ± 4.81 days (P <0.01). The urinary protein negative days in the treatment group were 4.03 days ± 1.87 days and that in the control group was 7.52 days ± 3.53 days (P <0.01). The mean days of urea nitrogen in the treatment group was 6.12 days ± 3.18 days and 10.21 days ± 4.72 days in the control group (P <0.01). The complication and mortality in the treatment group were significantly less than those in the control group . Prompt combination of two drugs can indeed reduce blood pressure, reduce urinary protein excretion and improve renal function, and no significant adverse reactions.