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粘附分子(AM)与正常皮肤的自身稳定性有关,也与皮肤病病因有关。AM 由β_1整合因子、β_2整合因子及选择因子组成。β_1整合因子也称极迟激活的抗原(VLA),因为在体外经抗原刺激后2～4周在淋巴细胞上才有VLA-1及 VLA-2出现,但也有一些 VLA 分子在非激活的白细胞和非造血细胞上表达。诱导 VLA 的表达可影响血管外白细胞的迁移。淋巴细胞相关功能抗原1(LFA-1)是β_2整合因子的一个成员,与细胞间粘附分子1(ICAM-1)相互作用,ICAM-1可在各种细胞
Adhesion molecules (AM) are related to the stability of normal skin and are also related to the etiology of skin diseases. AM consists of β_1 integration factor, β_2 integration factor and selection factor. The β_1 integration factor is also called very late activated antigen (VLA) because VLA-1 and VLA-2 appear on lymphocytes two to four weeks after antigen stimulation in vitro, but there are also some VLA molecules in inactive white blood cells. And expressed on non-hematopoietic cells. The induction of VLA expression can affect the migration of extravascular white blood cells. Lymphocyte-associated functional antigen 1 (LFA-1) is a member of the β_2 integration factor that interacts with intercellular adhesion molecule 1 (ICAM-1), and ICAM-1 is available in various cells.