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在pH6.2的Britton-Robinson缓冲介质中,替米沙坦(TMST)与生物染色剂固绿FCF(FGF)反应,形成离子缔合物,溶液颜色发生明显改变,最大正、负吸收波长分别位于598、632 nm,从而建立光度法测定替米沙坦。在598、632 nm处,替米沙坦分别在0～1.35×10-5mol/L、0～1.05×10-5mol/L范围内遵从比尔定律,表观摩尔吸光系数分别为7.65×104 L.mol-1.cm-1、1.70×105 L.mol-1.cm-1,检出限分别为8.22×10-7 mol/L和3.20×10-7 mol/L。该方法可用于临床用药、血样及尿样中替米沙坦的测定。
In pH6.2 Britton-Robinson buffer medium, telmisartan (TMST) reacts with biological dye fixing green FCF (FGF) to form ion-association complex. The color of solution changes obviously, and the maximum positive and negative absorption wavelength At 598,632 nm, thus establishing a spectrophotometric assay for telmisartan. Beer ’s law was obeyed at the range of 0 ~ 1.35 × 10-5mol / L and 0 ~ 1.05 × 10-5mol / L at 598,632 nm. The apparent molar absorptivities were respectively 7.65 × 104 L. mol-1.cm-1,1.70 × 105 L.mol-1.cm-1, the detection limits were 8.22 × 10-7 mol / L and 3.20 × 10-7 mol / L, respectively. The method can be used for clinical medication, determination of telmisartan in blood samples and urine samples.