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作者将32名中年原发性高血压患者随机分成两组,用双盲法比较甲基多巴和心得安对血脂和脂蛋白的影响。甲基多巴组14例;心得安组18例。二组间体重、身高、年龄无明显差异。实验过程中两组受试者平均体重均无明显改变;并对一些主要食物、烟、酒及体力活动进行了记录,两组间亦无明显差异。实验分四期进行:受试者先用安慰剂4周;而后开始用药6周:甲基多巴每天用量500—2000mg,心得安每天用量80—320mg 直到平卧位舒张压低于90mmHg 或达到用量的最大限度时为止;第一个6周用药后,再以所确定的药量维
The author of 32 middle-aged patients with essential hypertension were randomly divided into two groups, a double-blind method comparing the impact of methyldopa and propranolol on blood lipids and lipoprotein. Methyl dopa group of 14 cases; propranolol group 18 cases. There was no significant difference in body weight, height and age between the two groups. During the experiment, the average body weight of the two groups of subjects had no significant change; some major food, tobacco, alcohol and physical activity were recorded, there was no significant difference between the two groups. The experiment was divided into four phases: the subjects first placebo for 4 weeks; and then began to use drugs for 6 weeks: Methyl Dopa daily dosage of 500-2000mg, safe daily dosage of 80-320mg until the supine position diastolic blood pressure below 90mmHg or reach the dosage Of the maximum date; the first six weeks after treatment, and then to determine the dose of Victoria