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非甾体抗炎药(NSAIDs)是胃部损害的常见病因之一,临床上亦常无症状,而需胃镜检查来诊断。本研究旨在检测口服通透性试验对诊断NSAIDs引起胃十二指肠损伤的价值。 动物实验:1.对雄性白兔皮下注射消炎痛(20mg/kg·12h)1~7次,于三次注射后开始发生胃窦溃疡,溃疡数目及大小随消炎痛用量增高而增多,病变可被同时用米索前列醇完全防止。2.胃通透性检查:管饲含蔗糖1mmol/L和100μCi[~(14)C]蔗糖后15、30、45及
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the common causes of stomach damage. They are often clinically asymptomatic and require endoscopy for diagnosis. The aim of this study was to determine the value of the oral permeability test in the diagnosis of gastroduodenal lesions caused by NSAIDs. Animal experiments: 1. Male rabbits were injected subcutaneously with indomethacin (20mg / kg · 12h) 1 ~ 7 times. Gastric ulcer began to occur after three injections. The number and size of ulcers increased with the increase of indomethacin. The lesions could be At the same time with misoprostol completely prevent. Gastric permeability test: tube containing sucrose 1mmol / L and 100μCi [~ (14) C] sucrose 15,30,45 and