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复方 MTBE 乳剂是胆结石灌注溶石剂。研究显示:由 MTBE 与EOTA 等组成的复方乳剂剂型稳定,刺激性小,溶石作用优异。既能溶解胆固醇结石,又能溶解胆色素结石及黑胆石,其药效明显优于复方桔油乳剂及纯MTBE。实验还表明,该药对豚鼠的胆囊运动、十二指肠和 Qddis 括约肌的生物电均无明显影响。用药后,肝肾功能无明显改变,肝、胆及十二指肠的组织学变化与对照组无明显差异。结果证示:用10%的 MTBE 乳剂进行临床应用,10例胆结石病人,经胆道灌注3~10次,1例结石消失,7例结石明显缩小,2例无效,使用过程病人无明显副作用。本乳剂是一种安全有效的胆结石直接溶石药物。
The compound MTBE emulsion is a stone infused stone solution. Studies have shown that: Compound emulsion formulations composed of MTBE and EOTA are stable, have little irritating effect, and have excellent solute action. It not only dissolves cholesterol stones, but also dissolves gallstone pigments and black gallstones. Its efficacy is obviously better than compound orange oil emulsion and pure MTBE. The experiment also showed that the drug had no significant effect on gallbladder movement, bioactivity of duodenum and Qddis sphincter in guinea pigs. After administration, there was no significant change in liver and kidney function, and the histological changes in liver, gallbladder and duodenum were not significantly different from those in the control group. The results showed that: with 10% of the MTBE emulsion for clinical use, 10 patients with gallstones, bile duct perfusion 3 to 10 times, 1 case of stone disappeared, 7 cases of stone was significantly reduced, 2 cases of invalid, no significant side effects of patients during use. The emulsion is a safe and effective drug for direct dissolution of gallstones.