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目的分析甲型H1N1流感患者病毒核糖核酸(RNA)阴转的规律和特点。方法对北京地坛医院收治的38例甲型H1N1流感确诊患者的RNA转归情况、可能影响RNA转归的相关因素进行统计分析。结果甲型H1N1流感患者病毒RNA一般在病程的第6天发生阴转,热程越长、流感样症状持续时间越长,RNA阴转的时间越长。早期应用磷酸奥司他韦抗病毒治疗可促进RNA阴转、缩短热程和促使症状恢复,但性别、年龄不影响RNA的阴转。结论体温和抗病毒治疗是影响甲型H1N1流感患者病毒RNA阴转的主要因素,热程、流感样症状持续时间也有一定影响,但仍有必要继续观察和探索。
Objective To analyze the rules and characteristics of virus RNA (RNA) transversion in patients with influenza A (H1N1). Methods A total of 38 patients with confirmed H1N1 influenza in Beijing Ditan Hospital were enrolled in this study. Results The virus RNA of patients with influenza A (H1N1) generally turned negative on the 6th day of the disease course. The longer the heat history, the longer the duration of the flu-like symptoms and the longer the RNA negative turn. Early application of oseltamivir antiviral therapy can promote RNA negative conversion, shorten the heat stroke and promote the recovery of symptoms, but gender, age does not affect the RNA of the female. Conclusions Body temperature and antiviral therapy are the main factors influencing the negative conversion of viral RNA in patients with swine influenza A (H1N1). The duration of fever and flu-like symptoms is also affected. However, it is still necessary to continue the observation and exploration.