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目的观察伊贝沙坦对糖尿病肾病的防治作用。方法观察伊贝沙坦干预的糖尿病大鼠的肾组织形态学改变,检测肾组织NF-κB活性,测定血清TNF-α水平。结果伊贝沙坦干预的糖尿病大鼠的肾组织形态学改变明显优于无干预组,肾小球基底膜厚度、肾小球内细胞数和单个核细胞数显著少于对照组,NF-κB活性、TNF-α水平与基底膜厚度呈正相关。结论伊贝沙坦可能通过抑制NF-κB,减轻过度的炎症反应而延缓DN的发生发展。
Objective To observe the prevention and treatment of irbesartan on diabetic nephropathy. Methods The morphological changes of kidney in diabetic rats treated with irbesartan were observed. The activity of NF-κB in renal tissue was measured and the level of serum TNF-α was measured. Results Irbesartan intervention in diabetic rats morphological changes was significantly better than the non-intervention group, the glomerular basement membrane thickness, the number of glomerular cells and mononuclear cells was significantly less than the control group, NF-κB Activity, TNF-α level and basement membrane thickness was positively correlated. Conclusion Irbesartan may delay the occurrence and development of DN by inhibiting NF-κB and relieving excessive inflammatory reaction.