抗肿瘤药物毒性较大,常见的有骨髓毒性、胃肠道反应、脱发及免疫抑制等。因为骨髓造血细胞、消化道上皮细胞、毛囊细胞及免疫细胞等增殖较快,DNA合成较速,因而易受抗肿瘤药物的作用。心、肝、肾、肺等实质器官为非增殖型器官,一般说来,抗肿瘤药物对这些脏器的毒性较小,但有些药物(主要是蒽环类抗生素)对心脏有明显毒性,亦有一些药物于大剂量时可影响心功能,产生心脏毒性。兹就抗肿瘤药物与心脏毒性作一简述。 Antitumor drugs more toxic, common myelotoxicity, gastrointestinal reactions, hair loss and immune suppression. Because bone marrow hematopoietic cells, gastrointestinal epithelial cells, hair follicles and immune cells proliferate faster, faster DNA synthesis, which is susceptible to anti-tumor drugs. In general, antitumor drugs are less toxic to these organs, but some drugs (mainly anthracycline antibiotics) are obviously toxic to the heart. Also, some organs, such as heart, liver, kidney and lung, are non-proliferative organs. Some drugs can affect heart function at high doses, resulting in cardiotoxicity. Here is a brief description of antitumor drugs and cardiotoxicity.