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目的探讨青年人缺血性脑卒中与抗心磷脂抗体(ACA)的关系及对预后的影响。方法测定青年人脑卒中组73例和健康体检者(对照组)30例患者血清ACA的阳性率,计算其异常率并进行比较。按脑卒中患者临床神经功能缺损程度评分(CNFDS)标准对患者进行评分。结果病例组ACA阳性率高于对照组(P<0.001);病例组中,ACA阳性者中多灶脑梗死率高于ACA阴性者(P=0.016);ACA阳性者中再发脑卒中高于ACA阴性者(P=0.040);病例组中ACA阳性者患者CNFDS评分较高,中位数为18(6～35),且预后不良。结论ACA可作为临床评价脑梗死严重程度和预后的生物学指标。
Objective To investigate the relationship between ischemic stroke and anticardiolipin antibody (ACA) in young people and prognosis. Methods The positive rate of serum ACA in 73 young stroke patients and 30 healthy volunteers (control group) was measured, and their abnormal rates were calculated and compared. The patients were scored according to the CNFDS score of stroke patients. Results The positive rate of ACA in case group was higher than that in control group (P <0.001). In case group, the rate of multifocal infarction in ACA positive group was higher than that of ACA negative group (P = 0.016) Patients with ACA-positive cases had a higher CNFDS score with a median of 18 (6 to 35) and a poor prognosis. Conclusion ACA can be used as a biological index to evaluate the severity and prognosis of cerebral infarction.