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Ph~1阳性的慢粒仍然是难以治愈的血液系统肿瘤。自从应用马利兰后,如今还无其它治疗能明显地延长生存朗,但使用马利兰的平均生存期仅比不接受任何治疗的病人长10个月。迄今除额外的染色体异常外,尚无其它肯定的预后指标。作者报道1例用马利兰诱导存活了25年,有自发性核型转化的慢粒患者。患者,女性,54岁。1958年5月诊断为慢粒。给予马利兰诱导,5月后白细胞降至6600/mm~3。临床上脏器肿大消失。1959年3月复发。再次给予马利兰
Ph ~ 1-positive CML remains a refractory hematological tumor. Since the introduction of Maryland, there is no other treatment that can significantly prolong the survival of Long, but the average survival of the use of Maryland is only 10 months longer than patients who did not receive any treatment. To date there are no other positive prognostic indicators except for extra chromosomal abnormalities. The authors report a case of CML with 25-year-old spontaneous karyotypic transformation induced by maryland. Patient, female, 54 years old. May 1958 diagnosis of chronic particles. Give Maryland induction, white blood cells dropped to 6600 / mm ~ 3 after May. Clinical organ enlargement disappeared. March 1959 recurrence. Give Maryland again