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目的研究云南白族育龄妇女人群雌激素-β(ER-β)受体基因多态性的分布特征及与其他种族的差异。方法以196例云南白族育龄妇女人群为研究对象,分析其ER-β基因rs1256049(RsaⅠ)和rs4986938(AluⅠ)位点的基因型频率和等位基因频率的分布特征,同时与其他的人群结果进行比较。结果 RsaⅠ位点基因型为AA的有20例(10.2%)、为AG的有106例(54.1%)、为GG的有70例(35.7%),AluⅠ位点基因型为AA的有1例(0.5%)、为AG的有67例(34.2%)、为GG的有128例(65.3%)。结论云南白族育龄妇女人群RsaⅠ和AluⅠ位点多态性的分布与其他种族存在一定差异。
Objective To study the distribution of estrogen-β (ER-β) receptor gene polymorphism and its differences with other races in the women of childbearing age in Bai nationality in Yunnan province. Methods A total of 196 Chinese women of childbearing age in Yunnan were recruited. The distribution of rs1256049 (RsaⅠ) and rs4986938 (AluⅠ) loci were analyzed with other population results Compare Results There were 20 cases (10.2%) with AA genotype in RsaⅠ locus, 106 cases (54.1%) with AG, 70 cases (35.7%) with GG, 1 case with AA genotype in AluⅠ locus (0.5%), 67 (34.2%) for AG, and 128 (65.3%) for GG. Conclusion The distribution of polymorphisms of Rsa I and Alu I loci in Yunnan women of childbearing age is different from other races.