本文根据甲氧苄氨嘧啶(TMP)的电位滴定曲线用交流示波极谱中和滴定法测定复方新诺明片中TMP的含量,不受磺胺甲基异恶唑的影响,方法简单、结果准确、终点直观、重现性好、易于掌握。本法与药典方法对照,测定结果基本一致,本方法的回收率平均值为100.0%,变异系数为0.35%。 In this paper, according to the potential titration curve of trimethoprim (TMP), the content of TMP in compound cotrimoxazole tablets was determined by AC-Oscillopolarographic neutralization titration method without the influence of sulfamethoxazole. The method was simple and the results Accurate, end-point intuitive, reproducible, easy to grasp. The method and the pharmacopoeia control method, the determination of the results are basically the same, the recovery rate of this method was 100.0%, the coefficient of variation of 0.35%.