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目的:探讨联合检测尿微量白蛋白(mAlb)、转铁蛋白(TRF)和β2-微球蛋白(β2-MG)对早期糖尿病肾病(DN)的意义。方法:用免疫散射比浊法检测糖尿病患者晨尿中mAlb、TRF和β2-MG的含量,并将患者按尿常规蛋白定性结果分成尿蛋白阴性组、尿蛋白阳性组,另设正常人组为阴性对照组,进行比较分析。结果:尿蛋白阴性组与尿蛋白阳性组mAlb、TRF和β2-MG与阴性对照组比较,差异均有非常显著性意义(P<0.01);mAlb、TRF和β2-MG尿蛋白阴性组与尿蛋白阳性组比较,差异均有非常显著性意义(P<0.01)。各组间阳性检出率存在非常显著性差异(P<0.01)。结论:尿mAlb、TRF和β2-MG,都是诊断早期DN较敏感的指标,3项指标联合检测能大大提高检测灵敏度,对于监测早期DN的发生和病情发展有重要意义。
Objective: To investigate the significance of combined detection of urinary microalbumin (mAlb), transferrin (TRF) and β2-microglobulin (β2-MG) on early diabetic nephropathy (DN). Methods: The contents of mAlb, TRF and β2-MG in morning urine of diabetic patients were detected by immune nephelometry. The patients were divided into urinary protein negative group and urine protein positive group according to the results of urine routine protein. Negative control group, comparative analysis. Results: There was significant difference between mAlb, TRF and β2-MG in urine protein negative group and urine protein positive group and negative control group (P <0.01) Protein positive group, the difference was significant (P <0.01). There was a very significant difference in the positive detection rate among the groups (P <0.01). Conclusions: Urinary mAlb, TRF and β2-MG are both sensitive indicators for the diagnosis of early DN. Combined detection of 3 indexes can greatly improve the sensitivity of detection, and is of great significance for monitoring the occurrence and progression of early DN.