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2型转谷氨酰胺酶(transglutaminase 2,TG2)是转谷氨酰胺酶家族成员之一,其作为一种多功能酶可通过激活多条信号通路(如PI3K/AKT途径、NF-κB途径、m TOR途径、RAS/MAPK途径等)调控肿瘤(如胰腺癌、肠癌、肝癌等)发生、发展、侵袭及耐药,在妇科肿瘤尤其是宫颈癌及卵巢癌的病理生理进程中可能也扮演了重要的角色,但具体机制尚不清楚。故本文通过对TG2结构和分布、活性调控以及当前关于TG2在宫颈癌和卵巢癌的研究进展进行综述,为宫颈癌及卵巢癌的治疗提供一些新的思路。
Transglutaminase 2 (TG2), a member of the transglutaminase family, acts as a multifunctional enzyme by activating multiple signaling pathways (eg, the PI3K / AKT pathway, the NF-κB pathway, m TOR pathway, RAS / MAPK pathway, etc.) to regulate the occurrence, development, invasion and resistance of tumors (such as pancreatic cancer, bowel cancer, liver cancer, etc.) and may also play a role in the pathophysiological process of gynecological tumors, especially cervical cancer and ovarian cancer The important role, but the specific mechanism is not clear. Therefore, this review summarizes the structure, distribution and activity of TG2 as well as the current research progress on TG2 in cervical and ovarian cancer and provides some new ideas for the treatment of cervical cancer and ovarian cancer.