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目的 探讨新生儿缺氧缺血性脑病血小板参数的变化及对临床指导意义。方法 对 1999年 10月～ 2 0 0 1年 5月被确诊为HIE的 5 0例新生儿的血小板数 (PLT)、平均血小板体积 (MPV)及血小板体积分布宽度(PDW)进行动态观察 ,并与 2 7例正常足月儿对比。结果 ⑴HIE患儿急性期PLT较正常儿明显降低 (P <0 0 1) ,MPV和PDW较正常儿明显增高 (P <0 0 5 ) ,两组恢复期PLT、MPV、PDW之间无明显差异 (P >0 0 5 )。⑵HIE患儿PLT随HIE病情加重而降低 (P <0 0 1) ,而MPV、PDW则随病情加重而增大 (P <0 0 5 )。结论 动态观察HIE患儿血小板参数 ,可作为判断病情严重程度的指标。
Objective To investigate the changes of platelet parameters in neonates with hypoxic-ischemic encephalopathy and its clinical significance. Methods The platelet count (PLT), mean platelet volume (MPV) and platelet volume distribution width (PDW) of 50 neonates diagnosed as HIE from October 1999 to May 2001 were observed dynamically. Contrast with 27 normal infants. Results (1) PLT in acute HIE children was significantly lower than that in normal children (P <0.01), and MPV and PDW were significantly higher than those in normal children (P <0.05). There was no significant difference in PLT, MPV and PDW between two groups (P> 0 0 5). (2) The PLT of HIE decreased with the increase of HIE (P <0.01), while the MPV and PDW increased with the increase of HIE (P <0.05). Conclusion Dynamic observation of platelet parameters in children with HIE can be used as an indicator of the severity of the disease.