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吩嗪类化合物有抗分枝杆菌的作用于1948年已有报告。一种吩嗪类化合物——B283在1952年便用于麻风病临床治疗,结果10例患者中有4例发生了肝损害,以后这个衍化物便未再应用。张永泰发现氯苯吩嗪(B663)对鼠麻风分枝杆菌有效,1962年才又用B663治疗麻风病。B663在麻风患者中不仅证明有抗菌作用,而且对耐砜类药的菌株有效;它有抗炎作用,所以对麻风性结节性红斑和界线类麻风向结核样型麻风反应患者亦有效。Carville麻风医院用B663的适应症是:①生育年龄女性发生慢性结节性红斑禁用呔咪哌啶酮者;②界线类麻
Phenazine compounds have anti-mycobacterial effects have been reported in 1948. A phenazine compound, B283, was used in the clinical treatment of leprosy in 1952. As a result, 4 of 10 patients developed liver damage, and the derivative was not used anymore. Zhang Yongtai found that chlorpheniramine (B663) on Mycobacterium leprae effective in 1962 and B663 treatment of leprosy again. B663 in leprosy patients not only proved antimicrobial effect, but also resistant to sulfonylurea strains; it has anti-inflammatory effects, so the leprosy nodular erythema and borderline leprosy tuberculosis-like leprosy patients are also effective. Carville leprosy hospital with B663 indications are: ① reproductive age women with chronic nodular erythema banned clopidopentone; ② borderline hemp