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系统性硬皮病是一种自身免疫性结缔组织病,该病以出现微血管损伤及自身免疫系统的异常为特征,导致皮肤增厚和内脏器官的纤维化,并伴随有自身抗体的出现。这些自身抗体与不同的临床表型紧密相关,对疾病的病因、诊断、治疗及预后提供了很大帮助。
Systemic scleroderma is an autoimmune connective tissue disease characterized by the appearance of microvascular damage and abnormalities in the autoimmune system leading to thickening of the skin and fibrosis of the internal organs accompanied by the appearance of autoantibodies. These autoantibodies are closely related to different clinical phenotypes, and are of great help to the etiology, diagnosis, treatment and prognosis of the disease.