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目的 探讨一氧化氮 (NO)和白细胞介素 8(interleukin 8,IL 8)、肿瘤坏死因子 α(tumornecrosisfactor α ,TNF α)在分泌性中耳炎发生和转归中的作用。方法 检测 5 8例 (80耳 )分泌性中耳炎患者血浆和中耳积液中NO、IL 8及TNF α ,并用 2 3例健康人血浆作对照。结果 NO、IL 8及TNF α在中耳积液中阳性表达率分别为 1 0 0 %、82 2 %和 71 4 % ;患者组三者的血浆含量较对照组高 (P <0 0 5 ) ,中耳积液的含量较血浆中高 (P <0 0 1 )。病程短者IL 8含量高 (P <0 0 1 ) ;病程长者NO及TNF α含量高 (P <0 0 5 )。浆液性积液组IL 8含量高 (P <0 0 1 ) ;粘液性积液组NO及TNF α的含量高(P <0 0 5 )。NO含量与TNF α含量呈正相关。结论 NO、IL 8、TNF α可能是中耳积液形成的诸多介质中的 3种 ;IL 8在疾病早期参与机体的防御反应 ,促进浆液性中耳积液产生 ;NO和TNF α与疾病的持续状态相关 ,并参与中耳积液中粘蛋白的分泌。
Objective To investigate the role of nitric oxide (NO) and interleukin 8 (IL 8) and tumor necrosis factor α (TNF α) in the pathogenesis and outcome of secretory otitis media. Methods Fifty-eight cases (80 ears) of otitis media with effusion were measured in plasma and middle ear effusion NO, IL 8 and TNFα, and 23 healthy human plasma as a control. Results The positive rates of NO, IL-8 and TNF-α in middle ear effusion were 100%, 82 2% and 71 4%, respectively. The plasma levels of the three groups were higher than those of the control group (P <0.05) , And the content of middle ear effusion was higher than that in plasma (P <0.01). The duration of disease was high in IL 8 (P <0.01), while the duration of disease was higher in patients with chronic obstructive pulmonary disease (P <0.05). Serum IL8 levels were higher in serous effusion group (P <0.01), and higher in NO and TNFα in mucinous effusion group (P <0.05). NO content and TNFα content was positively correlated. Conclusions NO, IL 8 and TNFα may be the three mediators of middle ear effusion. IL 8 participates in the body’s defensive response in the early stage of the disease and promotes the production of serous effusion. NO and TNFα are associated with disease Continuous state related, and participate in the secretion of mucins in the middle ear effusion.