Preservation of non-heart-beating donor livers in extracorporeal liver perfusion and histidine-tryto

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AIM: To compare the preservation of non-heart beating donor (NHBD) livers in cold histidine-trytophan ketoglutarate (HTK) solution and extracorporeal liver perfusion (ECLP).METHODS: Livers harvested from health pigs were stored for 10 h in cold HTK solution (group A, n=4)or perfused with oxygenated autologous blood at eody temperature (group B, n = 4). Both groups were then tested on the circuit for 4 h. Bile production,hemodynamic parameters, hepatocyte markers andreperfusion injury of extracorporeal livers were testedin each group. Liver tissues from each group wereexamined at the end of reperfusion.RESULTS: At 1, 2, 3 and 4 h after reperfuSion, bileproduction, hemodynamic parameters, hepatocytemarkers and reperfusion injury of livers in group A werestatistically different from those in group B (P < 0.05 orP < 0.01).CONCLUSION: ECLP is better than HTK solution topreserve NHBD livers. ECLP can assess the graft viabilitybefore liver transplantation.
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