论文部分内容阅读
目的:研究5-氟尿嘧啶(5-FU)与生长抑素联合应用在治疗胃肠癌中的疗效。方法:选择经过确诊的胃肠癌患者74人,分为5-FU单组治疗组(26例)和5-FU及生长抑素联合治疗组(5-FUSS组,48例),5-FU组采用350mg/d剂量,静脉滴注,5-FUSS组行350mg/d剂量5-FU,同时皮下注射伐普肽3.5mg/m2,连用7d为一周期,休息2周后再用一周期,共治疗2周期。TNM分期Ⅲ期26例,5-FU组10例,5-FUSS组16例;Ⅳ期48例,5-FU组16例,5-FUSS组32例。结果:5-FUSS组与5-FU组比较可以明显提高胃肠癌的治疗效果,完全缓解(CR)4例、部分缓解(PR)12例、稳定(SD)24例、进展(PD)8例,总有效率(ORR)为33.3%,肿瘤抑制率为83.3%,两组患者均出现不同程度的不良反应,以恶心、呕吐、脱发、血细胞减少为主。结论:5-FU及生长抑素联合给药在治疗胃肠癌中具有很好的效果,病人耐受性好,具有一定的推广价值。
Objective: To study the efficacy of 5-fluorouracil (5-FU) combined with somatostatin in the treatment of gastrointestinal cancer. Methods: A total of 74 patients with gastrointestinal cancer were selected and divided into 5-FU single group (26 cases), 5-FU group and somatostatin combined group (48 cases) Group 350mg / d dose intravenous drip, 5-FUSS group 350mg / d dose of 5-FU, and subcutaneously injected valproate 3.5mg / m2, once every 7d for a period of rest 2 weeks and then a cycle, A total of 2 cycles. There were 26 cases in TNM stage Ⅲ, 10 cases in 5-FU group and 16 cases in 5-FUSS group, 48 cases in stage Ⅳ, 16 cases in 5-FU group and 32 cases in 5-FUSS group. Results: Compared with 5-FU group, 5-FUSS group could significantly improve the therapeutic effect of gastrointestinal cancer. There were 4 cases of complete remission (CR), 12 cases of partial remission (PR), 24 cases of stable (SD) Cases, the total effective rate (ORR) was 33.3%, tumor suppression rate was 83.3%, both groups of patients showed varying degrees of adverse reactions, nausea, vomiting, hair loss, cytopenia. Conclusion: The combination of 5-FU and somatostatin has a good effect in the treatment of gastrointestinal cancer. The patients are well tolerated and have a certain promotion value.