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Ｐ＜０．０１。讨论Ｋａｖａｌｃｈｕｋ等发现卵巢癌外周血ＴＮＦ升高，Ｂｅｒｎａｒｄ等观察卵巢癌、子宫内膜癌血ＴＮＦ水平也升高。本文结果显示，血ＴＮＦ水平在卵巢恶性肿瘤、子宫体癌、宫颈癌均高于良性组及正常组，与文献报道一致。国内外文献均报道，肺癌、乳癌、喉癌、直结肠癌组织产生ＰＧＥ２，外周血中其水平也升高。本文结果证实ＰＧＥ２在妇科恶性肿瘤患者外周血ＰＧＥ２水平也升高，治疗后下降，与ＴＮＦ水平变化一致。作者单位：
P<0.01. Discussion Kavalchuk et al found that TNF increased in peripheral blood of ovarian cancer. Bernard et al. observed that TNF levels in ovarian cancer and endometrial cancer also increased. The results of this study showed that the levels of blood TNF in ovarian cancer, uterine body cancer, and cervical cancer were higher than those in benign and normal groups, consistent with the literature reports. Both domestic and foreign reports have reported that lung cancer, breast cancer, laryngeal cancer, and colorectal cancer tissue produce PGE2, and their levels in peripheral blood also increase. The results of this study confirmed that PGE2 levels in peripheral blood of patients with gynecological malignancy also increased, and decreased after treatment, consistent with changes in TNF levels. Author unit: