同型半胱氨酸检测作为血清学标志物已成为现在研究的热点;而肿瘤的发病率和死亡率已跃居各常见疾病的第2位。本文从同型半胱氨酸的合成、代谢基本环节以及代谢关键酶(亚甲基四氢叶酸还原酶、蛋氨酸合成酶、胱硫醚p合成酶)的遗传学角度和重要辅因子(叶酸、维生素B12)体内水平变化等方面,阐述了其与肿瘤的关系,以期为临床和科研提供一个特异性和敏感性都较好的指标。 Homocysteine ​​testing as a serological marker has become a hot topic nowadays; the incidence of cancer and mortality have leapt to the first two common diseases. This article from the homocysteine ​​synthesis, the basic aspects of metabolism and metabolic key enzymes (methylenetetrahydrofolate reductase, methionine synthase, cystathionine p synthetase) genetic point of view and important cofactors (folic acid, vitamins B12) in vivo level changes, etc., described its relationship with the tumor, with a view to clinical and research to provide a specific and sensitive indicators are good.