论文部分内容阅读
中性粒细胞胞外诱捕网是由DNA骨架、组蛋白、颗粒成分以及胞浆蛋白组成的网状物,它通过捕获致病微生物,抑制其扩散、灭活毒力因子以及清除病原体来发挥抗菌活性,中性粒细胞这种与其经典的趋化、吞噬作用不同的胞外杀菌方式发挥着重要的固有免疫应答作用。然而,中性粒细胞胞外诱捕网的产生是一把双刃剑。近年来有研究表明它可以导致凝血异常、刺激血栓形成并为其提供支架,但这一过程的机制并不十分清楚,可能与中性粒细胞胞外诱捕网的促凝活性以及凝血级联反应的激活有关。本文将就中性粒细胞胞外诱捕网及其与血栓形成之间关系的研究进展做一综述。
The neutrophil extracellular trapping network is a network of DNA scaffolds, histones, particulate components and cytoplasmic proteins that exert antimicrobial activity by trapping pathogenic microorganisms, inhibiting their proliferation, inactivating virulence factors, and clearing pathogens Activity, neutrophils and its classic chemotaxis, phagocytosis different from the extracellular bactericidal mode play an important innate immune response. However, the production of extracellular trapping neutrophils is a double-edged sword. In recent years, studies have shown that it can lead to abnormal coagulation, stimulate thrombosis and provide scaffolds, but the mechanism of this process is not very clear, and may be neutrophil extracellular trapping network procoagulant activity and coagulation cascade Related to the activation. This article reviews the progress of research on the relationship between neutrophil extracellular trapping and thrombosis.