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目的探讨应用微波联合保妇康栓治疗宫颈柱状上皮异位伴高危型人乳头瘤病毒(HPV)感染的临床疗效。方法将362例宫颈柱状上皮异位伴高危型HPV感染而宫颈液基薄层细胞学检查(TCT)排除宫颈上皮内瘤变和宫颈癌的患者随机分为观察组和对照组,观察组242例,于月经后3～5d行微波治疗,再于下次月经后开始阴道内放置保妇康栓2周(1次/d),连用3个月经周期。对照组120例:只行微波治疗。分别于微波治疗后2、4、6个月复查宫颈柱状上皮异位治疗效果,并于微波治疗后6个月复查宫颈高危型HPV和TCT,比较二组宫颈柱状上皮异位治疗效果和高危型HPV清除的情况。结果微波治疗后6个月复查,观察组和对照组宫颈柱状上皮异位有效率分别为98.5%和85.0%,二者比较差异有统计学意义(P<0.05);观察组和对照组宫颈高危型HPV转阴率分别为55.0%和38.0%,二者比较差异有统计学意义(P<0.05)。结论微波联合保妇康栓治疗宫颈柱状上皮异位伴高危型HPV感染可提高宫颈柱状上皮异位治疗有效率和高危型HPV清除率,值得临床推广。
Objective To investigate the clinical efficacy of microwave combined with Baofukang Suppository for the treatment of high risk human papillomavirus (HPV) infection in cervical columnar epithelium. Methods 362 cases of cervical columnar epithelial ectopic patients with high-risk HPV infection and cervical cytology-based cytology (TCT) excluded cervical intraepithelial neoplasia and cervical cancer were randomly divided into observation group and control group. The observation group included 242 cases , After 3 ~ 5d after menstruation microwave treatment, and then in the next menstrual vaginally placed in the vagina Baofukang suppositories for 2 weeks (1 / d), once every 3 menstrual cycles. Control group of 120 patients: only microwave treatment. The results of cervical columnar epithelial ectopic treatment were reviewed at 2, 4, and 6 months after microwave treatment respectively. High-risk HPV and TCT were retrospectively examined at 6 months after microwave treatment. The effect of cervical ectopic cervical heterotopic treatment and high-risk type HPV removal. Results After 6 months of microwave treatment, the ectopic effective rates of cervical columnar epithelium in the observation group and control group were 98.5% and 85.0%, respectively, with statistical significance (P <0.05). In the observation group and control group, the cervical high risk HPV-negative rate was 55.0% and 38.0%, the difference between the two was statistically significant (P <0.05). Conclusion Combined microwave and Baofukang Suppository for the treatment of high-risk HPV infection of cervical columnar epithelial ectopic patients can improve the effective rate of cervical columnar epithelial ectopic treatment and high-risk HPV clearance, which is worthy of clinical promotion.