目前治疗肝纤维化尚无理想的药物和方法。根据中医益气活血、解毒散结的治法，以黄芪、莪术、北豆根等中药为主制成芪术颗粒冲剂，用于肝纤维化的治疗，取得了较好的临床疗效，并于１９９６年列为国家九·五攻关课题。在此基础上，我们进行了该药的药效学研究。１　材料与方法 At present, there are no ideal drugs and methods for treating liver fibrosis. According to the traditional Chinese medicine method of replenishing qi, activating blood circulation, and detoxifying and dissolving knots, Zhishu Granules made mainly of Chinese herbs such as Astragalus membranaceus, Rhizoma Zedoariae, and Beidougen are used for the treatment of hepatic fibrosis and have achieved good clinical curative effect. In 1996, it was listed as a national ninth five-year research project. On this basis, we conducted a pharmacodynamic study of the drug. 1 Materials and Methods