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目的：探讨老年性白内障患者血、房水、晶体核中抗氧化酶和抗氧化物之间的相关关系及作用。方法：随机取符合条件的老年性白内障 ４４例（４４只眼）。超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅ ｄｉｓｍｕｔａｓｅ， ＳＯＤ）用黄嘌呤化酶法测定，丙二醛（ｍａｌｏｎｄｉａｌｄｅｈｙｄｅ， ＭＤＡ）用巴比妥酸反应比色法测定，谷胱甘肽过氧化物（ｇｌｕｔａｔｈｉｏｎｅ－ｐｅｒｏｘｉｄｅ， ＧＳＨ－ＰＸ）用改进的还原型谷胱甘肽消耗法测定，ＶｉｔＣ和ＶｉｔＥ分别用微量荧光法和比色法测定。结果：ＳＯＤ、ＭＤＡ、ＧＳＨ－ＰＸ、ＶｉｔＣ及ＶｉｔＥ在血、房水、晶体核中相互存在１４个明显相关方程（ｔ检验，Ｐ＜０．０１或＜０．０５）。结论：抗氧化酶之间和抗氧化物之间以及二者之间互相协调、制约的相关关系受到破坏可能是老年性白内障形成的原因之一。
Objective: To investigate the relationship and role of antioxidant enzymes and antioxidants in blood, aqueous humor and crystal nucleus in senile cataract patients. Methods: Forty-four patients (44 eyes) with senile cataract were selected randomly. Superoxide dismutase (SOD) was measured by xanthinease method, malondialdehyde (MDA) was measured by barbituric acid reaction colorimetric method, glutathione-peroxide GSH-PX) was determined by an improved reduced glutathione depletion assay, with VitC and VitE respectively determined by micro-fluorescence and colorimetric methods. Results: There were 14 significant correlations between SOD, MDA, GSH-PX, VitC and VitE in blood, aqueous humor and nucleus (t test, P <0.01 or <0.05). Conclusion: It is possible that one of the reasons for the formation of senile cataract may be the damage of the correlation between antioxidant enzymes and antioxidants and between them.