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目的探讨丙酸倍氯米松粉雾剂治疗中青年中度支气管哮喘合并过敏性鼻炎的疗效,寻求一种高效、经济、安全、可靠的给药途径和方法。方法 84例随机分为:治疗组41例经口吸再经鼻呼丙酸倍氯米松粉雾剂每次200μg,3次/d,富马酮替芬1mg,2次/d;对照组43例,经口吸再经口呼丙酸倍氯米松气雾剂250mg,3次/d,富马酮替芬1mg,2次/d,二组按需给予沙丁胺醇2.4mg,每日不过3次。疗程均为12周。结果治疗后二组在白天症状,夜间症状,哮喘和鼻炎的控制,FEV1、FEV1占预计值和PEF值比较治疗组改善显著优于对照组(经秩和检验P>0.01)。结论经口吸再经鼻呼丙酸倍氯米松粉雾剂的方式治疗青中年中度支气管哮喘合并过敏性鼻炎可取得较好的疗效,是一种高效、经济、安全、可靠的给药途径和方法。
Objective To investigate the efficacy of beclometasone dipropionate aerosol in treating middle-aged and moderate bronchial asthma with allergic rhinitis, and to find an efficient, economical, safe and reliable route of administration and method. Methods Eighty-four patients were randomly divided into treatment group (n = 41), oral inhalation and oral administration of beeraclitone benazepril 200μg, 3 times daily, fumactone 1 mg, For example, orally inhaled oral beclomethasone dipropionate aerosol 250mg, 3 times / d, fumactone for fentanyl 1mg, 2 times / d, the two groups were given albuterol 2.4mg, but 3 times a day . The course of treatment is 12 weeks. Results After treatment, the improvement of symptoms, nocturnal symptoms, asthma and rhinitis, FEV1 and FEV1 in the two groups were significantly better than those in the control group (rank sum test, P> 0.01). Conclusion Oral inhalation and nasal salbutamol bevermectin powder aerosol treatment of middle-aged mild bronchial asthma with allergic rhinitis can achieve better efficacy, is a highly efficient, economical, safe and reliable drug delivery Ways and methods.