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目的:探讨RKIP在舌癌组织及转移淋巴结中的表达及意义。方法:应用免疫组化法检测RKIP在60例舌癌组和癌旁组织表达情况,比较舌癌分化良好组和分化不良组RKIP表达,将舌癌淋巴结转移组和淋巴结无转移组RKIP表达进行比较。结果:舌癌组和癌旁组织相比,RKIP表达水平明显下降,两者之间有统计学差异(P<0.05)。舌癌分化良好组RKIP表达高,分化不良组表达低,RKlP与舌癌病理分级之间,有相关关系(P<0.05)。转移淋巴结RKIP表达低。结论:RKIP具有抑制舌癌转移的作用,其表达的上调能促进舌癌的分化,抑制舌癌的转移。
Objective: To investigate the expression and significance of RKIP in tongue cancer tissues and metastatic lymph nodes. Methods: The expression of RKIP was detected by immunohistochemistry in 60 cases of tongue cancer and paracancerous tissues. The expressions of RKIP in tongue cancer well-differentiated group and poorly differentiated group were compared, and the expression of RKIP in lymph node metastasis and non-lymph node metastasis of tongue cancer was compared . Results: The expression of RKIP in tongue cancer group was significantly lower than that in paracancerous tissues (P <0.05). The tongue cancer well-differentiated group RKIP expression is high, poorly differentiated group low expression, RKlP and tongue cancer pathological grade, there is a correlation (P <0.05). RKIP expression in metastatic lymph nodes is low. Conclusion: RKIP can inhibit the metastasis of tongue cancer. The upregulation of RKIP can promote the differentiation of tongue cancer and inhibit the metastasis of tongue cancer.