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FKN(fractalkine)是由体内多种组织细胞分泌的具有黏附功能的趋化因子,是目前发现的CX3C家族的惟一成员,具有CX3C基序、跨膜区、黏液样结构域的特殊结构。FKN因子对中性粒细胞、淋巴细胞、单核细胞等均有趋化作用。FKN因子能加快炎性因子的渗出,促进炎症级联反应的发生,从而参与多种疾病的发生、发展。本文就FKN与多种临床疾病的关系进行综述。
FKN (fractalkine) is an adhesive chemokine secreted by many kinds of tissue cells in the body. It is the only member of the CX3C family that has been found so far. FKN has the special structure of CX3C motif, transmembrane region and myxoid-like domain. FKN factor on neutrophils, lymphocytes, monocytes and other chemotactic effect. FKN factor can accelerate the exudation of inflammatory factors, promote the occurrence of inflammatory cascade, and thus participate in the occurrence and development of various diseases. This article reviews the relationship between FKN and various clinical diseases.