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目的:本研究旨在探究抗菌药物所致药物热的特点,以正确地认识药物,避免药物热引起的严重后果。方法:选择呼吸科2011-2014年发生的药物热20例,总结病例特点,对药物种类及实验室检查等结果进行回顾性分析。结果:20例患者在停药后48 h内体温均恢复正常。药物热发生中位时间为用药后第6 d,平均值为6.9 d,下午和夜间体温升高明显,最高温度在37.8~40.3℃之间,20例均出现相对缓脉,部分病例出现了转氨酶和血沉值升高。结论:临床医生应关注抗菌药引起药物热,尽早判断药物热,减少抗菌药的不合理使用。
Objective: This study aims to explore the characteristics of drug fever caused by antimicrobial agents to correctly understand the drug, to avoid the serious consequences of drug fever. Methods: 20 cases of drug fever occurred in 2011-2014 were selected, and the characteristics of cases were summarized. The types of drugs and the results of laboratory tests were retrospectively analyzed. Results: All patients in 20 patients returned to normal within 48 hours after drug withdrawal. Median fever occurred on the 6th day after treatment, with an average of 6.9 days. The body temperature increased significantly in the afternoon and at night. The maximum temperature ranged from 37.8 ° C to 40.3 ° C. All of the 20 cases showed relative slow pulse. In some cases, aminotransferase And ESR increased. Conclusion: Clinicians should pay attention to antibiotics caused drug fever, as early as possible to determine the drug fever, reduce the irrational use of antibacterial drugs.