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采用回顾性方法对 4 5例男性乳腺癌的临床表现、病理、腋淋巴结转移、激素受体情况及可能导致男性乳腺癌的病因进行了分析。结果发现 :发病中位年龄为 63岁 ,部分患者与雌激素、睾酮比例失调、局部接触放射线及遗传有关。4 5例患者均有乳晕下肿块 ,10 / 4 5例有乳头溢液 ,3 3/ 4 5例病理为浸润性导管癌。2 8例患者进行了改良根治术 ,腋淋巴结转移率为 57.1%。雌、孕激素受体阳性率均为 (73.3 % )。发病年龄比女性要晚 ,发病原因可能与雌激素 /睾酮比例失调、遗传、局部放射治疗存在一定的关系 ,临床上主要为无痛性肿块、乳头溢液 ,浸润性导管癌为主要类型 ,腋淋巴结转移率高 ,大部分患者雌孕激素受体阳性。
A retrospective analysis of the clinical manifestations, pathology, axillary lymph node metastasis, hormone receptor status and the etiology of male breast cancer that may lead to 45 male breast cancers was performed. The results showed that the median age of onset was 63 years, and some patients were related to the imbalance of estrogen, testosterone, local exposure to radiation and heredity. Forty-five patients had subarachal masses, 10/45 patients had nipple discharge, and 3 3/45 patients had invasive ductal carcinoma. Twenty-eight patients underwent modified radical mastectomy with axillary lymph node metastasis rate of 57.1%. The positive rates of estrogen and progesterone receptors were all (73.3%). The age of onset is later than that of women. The cause of the disease may be related to imbalance of estrogen/testosterone, genetics, and local radiation therapy. Clinically, it is mainly a painless mass and nipple discharge. Invasive ductal cancer is the main type. The lymph node metastasis rate is high, and most patients have positive estrogen and progesterone receptors.