核苷酸结合寡聚化结构域(nucleotide-binding oligomerization domain,NOD)样受体含有的pyrin结构域蛋白6(nucleotide-binding oligomerization domain-like receptor 6,NLRP6),其分子有3个主要结构域,即N端的Pyrin结构域、中部的NOD结构域和C端的亮氨酸富集重复结构域(leucine-rich repeat domain,LRR)。NLRP6在肠道中高表达在维持肠道微生物稳态和抗细菌免疫方面发挥重要作用,但其在肠道病毒感染过程中作用仍未知,作者应用脑心肌炎病毒(encephalomyocarditis virus,EMCV)感染模型对其展开研究。 The nucleotide-binding oligomerization domain-like receptor 6 (NLRP6) contained in the nucleotide-binding oligomerization domain (NOD) -like receptor has three major domains , Namely the N-terminal Pyrin domain, the central NOD domain and the C-terminal leucine-rich repeat domain (LRR). High expression of NLRP6 in the intestine plays an important role in the maintenance of intestinal microbial homeostasis and antibacterial immunity, but its role in the process of enterovirus infection is still unknown. The authors used encephalomyocarditis virus (EMCV) Start researching