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目的 :研究果糖二磷酸钠镁 (FDPM)对大鼠脑缺血—再灌注引起脑损伤的保护作用。方法 :自大鼠颈总动脉插入尼龙线栓栓塞大脑中动脉 ,造成大脑缺血 ,拔出线栓实现再灌注。脑缺血 10min后给予 40 0mg·kg- 1 FDPM ,40 0mg·kg- 1 FDP及 30mg·kg- 1 MgSO4,分别于脑缺血 1h再灌注 2h ,5h和 2 3h分别进行神经病学评分 ,并于脑缺血 1h再灌注 2 3h时测定脑梗塞面积及脑组织MDA含量 ,观察大脑组织病理学变化。结果 :FDPM降低脑血—再灌注大鼠神经病学评分 ,缩小脑梗塞面积 ,降低脑组织MDA含量 ,减轻光镜下脑组织的病理改变 ,其作用强于FDP或MgSO4。结论 :FDPM可显著保护大脑缺血再灌注引起的脑损伤 ,其作用优于单用FDP或MgSO4。
Objective: To study the protective effect of sodium magnesium fructose diphosphate (FDPM) on brain injury induced by cerebral ischemia-reperfusion in rats. Methods: Nylon thread embolized the middle cerebral artery from the common carotid artery of the rat, resulting in cerebral ischemia, pulling out the thrombus for reperfusion. After 10 min of cerebral ischemia, 40 0 mg · kg-1 FDPM, 40 0 mg · kg-1 FDP and 30 mg · kg-1 MgSO4 were given respectively. Neurological scores were respectively calculated at 1h, 2h, 2h and 1h after cerebral ischemia Cerebral infarction area and brain MDA content were measured at 1h reperfusion after cerebral ischemia for 1h, and histopathological changes were observed. Results: FDPM reduced neurological score, decreased infarct size, decreased MDA content in brain tissue and reduced pathological changes of brain tissue under light microscopy, which was stronger than FDP or MgSO4. Conclusion: FDPM can significantly protect brain from cerebral ischemia-reperfusion injury and its effect is better than using FDP or MgSO4 alone.