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目的 在以往工作的基础上 ,进一步证明瘘管刺激前庭诱发电位的应用价值。方法 14只健康白色红目豚鼠分成用药组 (8只 )和正常对照组 (6只 )。用药组每天肌肉注射庆大霉素 2 30mg/kg ,持续 5d。记录两组动物的前庭诱发电位。结果 扫描电镜证实该组动物壶腹嵴、囊斑毛细胞出现不同程度病理改变 ,基底膜毛细胞形态正常 ,瘘管刺激前庭诱发电位测试 ,见该诱发电位P1～P4各波振幅明显下降 ,与正常对照组比较有显著差异 ,而听性脑干反应 (ABR)测试结果两组未见显著性改变。结论 瘘管刺激前庭诱发电位可以作为显示前庭系病变客观和直接的观察指标 ,并有定位诊断价值
Objective To further prove the value of fistula stimulation of vestibular evoked potentials based on previous work. Methods Fourteen healthy white-red-headed guinea pigs were divided into medication group (n = 8) and normal control group (n = 6). The treatment group was given gentamicin 2 30 mg / kg intramuscularly every day for 5 days. The vestibular evoked potential was recorded in both groups of animals. Results Scanning electron microscopy confirmed that the ampulla of the animals showed varying degrees of pathological changes in the ampulla and cytoplasm of hair cells. The hair cells of the basilar membrane were normal and the fistula stimulated the vestibular evoked potential test. The amplitudes of P1 - P4 evoked potentials were obviously decreased, There was significant difference between the control group, but there was no significant difference between the two groups in the auditory brainstem response (ABR) test. Conclusions Fetal stimulation of vestibular evoked potentials can be used as an objective and direct observation indicator of vestibular diseases and has the value of localization diagnosis