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5. Preparation of ^99mTc-PQQE and preliminary biological evaluation for the NMDA receptor

Preparation of ^99mTc-PQQE and preliminary biological evaluation for the NMDA receptor

来源 :核技术：英文版 | 被引量 : 0次 | 上传用户：Shimq

【摘 要】

：

The 4,5-dioxo-4,5-dihydro-1H-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylic acid 2-ethyl ester 7,9-dimethyl ester (PQQE) was synthesized on the basis of Pyrroloqui

【作 者】

：

ZHOU Xingqin KONG Yanyan ZOU M 

【机 构】

：

KeyLaboratoryofNuclearMedicine

【出 处】

：

核技术：英文版

【发表日期】

：

2013年3期

【关键词】

：

NMDA受体 生物学评价 N-甲基-D-天冬氨酸受体 制备 吡咯喹啉醌 停留时间 生物学特性 放射性物质 PQQE  ^99mTc-PQQE  NMDA rec 

【基金项目】

：

Supported by National Natural Science Foundation of China （No.30770602） and Natural Science Foundation of Jiangsu Province, China （Nos. BK2010157 and BK2011167）

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论文部分内容阅读

The 4,5-dioxo-4,5-dihydro-1H-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylic acid 2-ethyl ester 7,9-dimethyl ester (PQQE) was synthesized on the basis of Pyrroloquinoline quinine (PQQ). 99m Tc-PQQE was prepared using stannous fluoride (SnF 2 ) as reducing age

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