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衰老已成为威胁人类健康的首要问题。截止2006年,全球≥65岁的老年人达5亿。肾脏是衰老较快的器官。肾脏衰老的组织学特征为肾动脉硬化,肾小球弥漫硬化,肾皮质减少,肾小管萎缩,间质纤维化。衰老的肾脏即使无形态学改变也会出现衰老相关性β-半乳糖苷酶(SA-β-gal)和P16INK4a表达增加。细胞衰老与上皮细胞转分化(epithe-lial-mesenchymal transition,EMT)是肾脏功能减退过程中的2个过程,彼此有着密切的联系。EMT的转录因子Twist和
Aging has become the number one threat to human health. As of 2006, the number of elderly people ≥65 years old reached 500 million. The kidneys are organs that age faster. The histological features of renal aging are atherosclerosis, diffuse glomerular sclerosis, renal cortical decrease, tubular atrophy and interstitial fibrosis. Aging-related kidneys show an increased expression of aging-related β-galactosidase (SA-β-gal) and P16INK4a even without morphological changes. Cell senescence and epithelial cell transdifferentiation (EMT) are two processes in the process of renal dysfunction, which are closely related to each other. EMT transcription factor Twist and