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目的对反复自然流产患者外周血CD4+CD25+调节性T细胞(CD4+CD25+Treg)百分率和IL-8、IL-10含量变化及可能产生的作用进行探讨。方法采用三色流式细胞术检测120例反复自然流产患者、120名正常妊娠妇女和120名正常非妊娠妇女外周血中CD4+CD25+Treg细胞比例,ELISA法检测上述研究对象IL-8和IL-10含量。结果反复自然流产组妇女外周血CD4+CD25+Treg细胞的百分率和IL-10水平明显低于正常非妊娠组和正常妊娠组,而IL-8明显高于正常非妊娠组和正常妊娠组,差异均有统计学意义(P均<0.05)。结论外周血CD4+CD25+Treg细胞、IL-8和IL-10水平与反复自然流产的发生有关。
Objective To investigate the changes of the percentage of CD4 + CD25 + regulatory T cells (CD4 + CD25 + Treg) and the levels of IL-8 and IL-10 in peripheral blood of patients with recurrent spontaneous abortion. Methods The proportion of CD4 + CD25 + Treg cells in peripheral blood of 120 patients with recurrent spontaneous abortion, 120 normal pregnant women and 120 normal non-pregnant women were detected by three-color flow cytometry. The levels of IL-8 and IL-8 -10 content. Results The percentage of CD4 + CD25 + Treg cells and the level of IL-10 in peripheral blood of recurrent spontaneous abortion group were significantly lower than those in normal non-pregnant group and normal pregnancy group, while IL-8 was significantly higher than that in normal non-pregnant group and normal pregnancy group All were statistically significant (P <0.05). Conclusion The levels of CD4 + CD25 + Treg cells, IL-8 and IL-10 in peripheral blood are correlated with the occurrence of recurrent spontaneous abortion.