~(99m)Tc标记蛋白质长时间来一直存在体内稳定性问题,甚至~(99m)Tc-人血清蛋白每小时仍有少许百分数的标记核素脱落.~(99m)Tc标记单克隆抗体证明具有同样困难.先加亚锡方法仅仅在~(99m)Tc标记高分子量黑色素抗体时才获得满意效果,而这些标记抗体在临床上已成功地应用于诊断表皮及眼黑色素瘤.通过螯合剂使~(99m)Tc与丙种球蛋白连接的技术 ~ (99m) Tc-labeled proteins persist for a long time in vivo stability problems and even ~ (99m) Tc-human serum proteins shed some percentage of labeled nucleotides every hour. ~ 99m Tc-labeled monoclonal antibodies have demonstrated The same as before.At first, the method of adding stannous is satisfactory only when the ~ (99m) Tc is labeled with high molecular weight melanin antibody, and these labeled antibodies have been successfully applied to the diagnosis of epidermal and ocular melanoma clinically.Through chelating agents, (99m) Tc gamma globulin technology