【摘 要】
:
以N,N-二甲基甲酰胺作溶剂,四丁基溴化铵作相转移催化剂,碳酸二甲酯作甲基化试剂,由四氢咔唑酮与氢氧化钾反应先合成钾盐,再经甲基化合成了N-甲基四氢咔唑酮。考察了钾盐与碳
【机 构】
:
黑龙江省科学院石油化学研究院,哈尔滨理工大学化学与环境工程学院,
论文部分内容阅读
以N,N-二甲基甲酰胺作溶剂,四丁基溴化铵作相转移催化剂,碳酸二甲酯作甲基化试剂,由四氢咔唑酮与氢氧化钾反应先合成钾盐,再经甲基化合成了N-甲基四氢咔唑酮。考察了钾盐与碳酸二甲酯的配比、反应时间、溶剂用量、催化剂及催化剂用量等因素对反应收率的影响。较佳合成条件为碳酸二甲酯∶四氢咔唑酮钾盐=2.5∶1,四丁基溴化铵用量为钾盐物质的量的2%,在100℃反应10h,反应摩尔收率可达80%以上。
Using N, N-dimethylformamide as a solvent, tetrabutylammonium bromide as a phase transfer catalyst and dimethyl carbonate as a methylation reagent, and reacting the tetrahydrocarbazolone with potassium hydroxide to synthesize a potassium salt first, N-methyl tetrahydrocarbazolone was synthesized by methylation. The effects of the ratio of potassium salt to dimethyl carbonate, the reaction time, the amount of solvent, the amount of catalyst and catalyst on the reaction yield were investigated. The optimum synthesis conditions are as follows: dimethyl carbonate: potassium tetrahydrocarbazone = 2.5: 1, tetrabutylammonium bromide is 2% of the amount of potassium salt and reacted at 100 ℃ for 10h. The molar yield of the reaction can be Up to 80%.
其他文献
Objective:To explore the relationship of overexpression of epidermal growth factor receptor(EGFR)in occurrence,development and treatment of breast cancer. Metho
Objective:A retrospective study was performed to analyze the impact of vascular invasion on prognosis in a series of radically resected non-small cell lung canc
[目的]评价两种手术入路治疗桡骨远端骨折对骨折愈合及腕关节、前臂功能的影响.[方法]采集本院2005年1月至2010年1月AO/ASIF分类中C型桡骨远端骨折完整病例43例,分别采用掌侧
Epithelial-mesenchymal transition (EMT) is a highly conserved process that has been well characterised in embryogenesis. Studies have shown that the aberrant ac
AIM: To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer (CRC).METHODS.Archival tumor samples we
Objective:To evaluate effects of different factors on proliferation capacity and cytotoxicity of induced cytokine induced killer(CIK)cells in vitro,so as to pro
Background Although it is recognized that bronchial smooth muscle cells (BSMCs) play a key role. In airway remodeling during chronic asthma, it is not well unde
Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal coloni
Biliary papillomatosis (BP) is an extremely rare pathological condition, which is characterized by papillary proliferation of the bile duct epithelia. Although
Background Ketanserin (KT), a selective serotonin (5-HT) 2-receptor antagonist, reduces peripheral blood pressure by blocking the activation of peripheral 5-HT