论文部分内容阅读
检测３４例儿童支气管哮喘血清ＩｇＧ亚类浓度、外周血Ｔ细胞亚群、Ｔ细胞增殖功能等变化。结果表明哮喘组血清ＩｇＧ１、ＩｇＧ３、ＩｇＧ４均值显著高于对照组；血清ＩｇＧ亚类增高检出率为１００％，其中以ＩｇＧ４增高居多；ＩｇＧ亚类缺陷检出率为４４．１１％，以ＩｇＧ２缺陷为主；外周血ＣＤ３＋、ＣＤ８＋细胞百分率及Ｔ细胞增殖反应明显降低，ＣＤ４＋／ＣＤ８＋细胞比值增高。提示儿童哮喘存在以ＩｇＧ４增高、ＩｇＧ２缺陷为主要特征的ＩｇＧ亚类失衡：Ｔ抑制细胞数量和（或）功能不足可能是导致ＩｇＧ亚类失衡的主要机制。
34 cases of children with bronchial asthma serum IgG subclass concentration, peripheral blood T cell subsets, T cell proliferation and other changes. The results showed that the mean serum IgG1, IgG3 and IgG4 levels in asthma group were significantly higher than those in control group. The positive rate of serum IgG subclass was 100%, of which the IgG4 level was the highest. The IgG subclass flaw detection rate was 44.11% The percentage of CD3 +, CD8 + cells and T cell proliferation in peripheral blood were significantly decreased and the ratio of CD4 + / CD8 + cells increased. It is suggested that imbalances of IgG subclasses, which are characterized by IgG4 elevation and IgG2 deficiency, may be the main mechanism of imbalance of IgG subclasses in children with asthma.