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为探讨ＡｇＮＯＲｓ变化对胃粘膜良、恶性病变的诊断价值，应用银染技术对５０例胃粘膜良、恶性病变进行ＡｇＮＯＲｓ计数，其中正常胃粘膜４例，萎缩性胃炎５例，异型增生９例，胃癌３２例（高分化型腺癌８例，低分化型腺癌１８例，未分化癌６例）。结果：正常胃粘膜、萎缩性胃炎和异型增生细胞核内ＡｇＮＯＲｓ颗粒均数，分别与胃癌各型癌细胞核内均数比较均有显著性差异（Ｐ＜０．０１）。可以认为这种方法有助于区别胃粘膜良、恶性病变及其预后的判断。
To investigate the diagnostic value of AgNORs changes in benign and malignant gastric mucosal lesions, silver staining was used to count AgNORs in 50 cases of gastric mucosal benign and malignant lesions, including 4 cases of normal gastric mucosa, 5 cases of atrophic gastritis, and 9 cases of dysplasia. There were 32 cases of gastric cancer (8 cases of highly differentiated adenocarcinoma, 18 cases of poorly differentiated adenocarcinoma, and 6 cases of undifferentiated carcinoma). Results: The average number of AgNORs in normal gastric mucosa, atrophic gastritis and dysplasia nuclei was significantly different from that in all types of cancer cells (P<0.01). This method can be considered to help distinguish the judgment of the benign and malignant gastric mucosal lesions and their prognosis.