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为探讨AgNORs变化对胃粘膜良、恶性病变的诊断价值,应用银染技术对50例胃粘膜良、恶性病变进行AgNORs计数,其中正常胃粘膜4例,萎缩性胃炎5例,异型增生9例,胃癌32例(高分化型腺癌8例,低分化型腺癌18例,未分化癌6例)。结果:正常胃粘膜、萎缩性胃炎和异型增生细胞核内AgNORs颗粒均数,分别与胃癌各型癌细胞核内均数比较均有显著性差异(P<0.01)。可以认为这种方法有助于区别胃粘膜良、恶性病变及其预后的判断。
To investigate the diagnostic value of AgNORs changes in benign and malignant gastric mucosal lesions, silver staining was used to count AgNORs in 50 cases of gastric mucosal benign and malignant lesions, including 4 cases of normal gastric mucosa, 5 cases of atrophic gastritis, and 9 cases of dysplasia. There were 32 cases of gastric cancer (8 cases of highly differentiated adenocarcinoma, 18 cases of poorly differentiated adenocarcinoma, and 6 cases of undifferentiated carcinoma). Results: The average number of AgNORs in normal gastric mucosa, atrophic gastritis and dysplasia nuclei was significantly different from that in all types of cancer cells (P<0.01). This method can be considered to help distinguish the judgment of the benign and malignant gastric mucosal lesions and their prognosis.