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对52例膀胱癌组织进行CD15抗原免疫组化检测,结果36例(69.2％)呈CD15阳性表达。CD15阳性率随着膀胱癌病理分级、临床分期上升而显著增高(P<0.05),在肿瘤直径≥2cm者显著高于<2cm者(P<0.05)。CD15阳性者复发和死亡率显著高于CD15阴性的复发和死亡率(P<0.01)。结果表明,CD15是膀胱癌高度恶性和预后不良的重要生物学指标。
Immunohistochemical detection of CD15 antigen in 52 cases of bladder cancer showed that CD15 expression was found in 36 cases (69.2%). The positive rate of CD15 was significantly increased with the pathological grade and clinical stage of bladder cancer (P <0.05), and significantly higher than 2 cm (P <0.05) when the diameter of tumor was more than 2 cm. Recurrence and mortality in CD15-positive patients were significantly higher than those in CD15-negative patients (P <0.01). The results show that, CD15 is a high degree of malignancy and poor prognosis of bladder cancer is an important biological indicators.