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目的:分析近年来南京医科大学第一附属医院不动杆菌属的流行情况及耐药现状,为临床合理应用抗菌药物提供指导依据。方法:收集2004年-2008年南京医科大学第一附属医院下呼吸道感染住院病人痰培养结果为不动杆菌的数据,用WHONET5.3软件统计分析。结果:2004年-2008年该院下呼吸道感染住院病人痰培养为不动杆菌属占所有病原体比例为7.0%-9.2%,占革兰阴性菌比例为13.9%-17.5%。革兰阴性菌中,不动杆菌始终排在前三位。不动杆菌对亚胺培南、美罗培南和头孢哌酮/舒巴坦较敏感。结论:下呼吸道感染病原体中不动杆菌占据越来越大的比例,减少医源性感染、合理选择的抗菌药物对于降低死亡率、提高医疗资源利用率至关重要。
Objective: To analyze the prevalence and drug resistance status of Acinetobacter in the First Affiliated Hospital of Nanjing Medical University in recent years, and provide the basis for clinical rational use of antimicrobial agents. Methods: The data of sputum culture results of sputum from hospitalized patients with lower respiratory tract infection in the First Affiliated Hospital of Nanjing Medical University from 2004 to 2008 were collected and analyzed by WHONET5.3 software. Results: From 2004 to 2008, sputum culture of sputum of Acinetobacter was 7.0% -9.2% in sputum culture and accounted for 13.9% -17.5% of gram-negative bacteria in hospital of lower respiratory tract infection. Gram-negative bacteria, Acinetobacter always ranked in the top three. Acinetobacter is more sensitive to imipenem, meropenem and cefoperazone / sulbactam. CONCLUSION: Acinetobacter plays a more and more important role in the pathogen of lower respiratory tract infection, reducing iatrogenic infection. A rational choice of antimicrobial agents is very important for reducing mortality and improving the utilization rate of medical resources.