消退素是近期通过脂质组学方法从炎症消退期腹腔渗出液中分离出的由ω-3多不饱和脂肪酸衍生的生物活性分子。新近研究发现消退素具有限制中性粒细胞的过度活化和募集、促进巨噬细胞吞噬凋亡中性粒细胞等功效,并在脓毒症、哮喘等炎症动物模型中展示出良好的抗炎促消退效应。因而,消退素成为继脂氧素之后备受关注的内源性促炎症消退新介质。 Destroyerin is a biologically active molecule derived from omega-3 polyunsaturated fatty acids recently isolated from the peritoneal exudate in the inflammatory regression phase by the lipidomic approach. Recent studies have found that exacerbation can limit the excessive activation of neutrophils and recruitment, and promote phagocytosis of macrophages and other apoptosis neutrophils and other effects, and in sepsis, asthma and other animal models of inflammation showed good anti-inflammatory Disappear effect. Therefore, the destroyer has become the new media of endogenous proinflammatory subsidence following the lipotoxins.